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A case series of potential mechanisms of acute coronary syndrome in a marijuana smoker cohort

Ashkan Tadayoni, Hira Chaudhary, Farla Jean-Louis, Ajibola Monsur Adedayo, Samy I McFarlane, Jonathan D Marmur and Erdal Cavusoglu

Delta 9-Tetrahydrocannabinol (THC) is the main psychoactive component of Marijuana, a derivative of the cannabis plant. It is one of the most commonly abused mind-altering drugs in the United States (U.S). It is postulated to have thrombogenic and vasospastic potential. In this case series, we describe three patients with acute coronary syndromes and marijuana use as a common factor resulting in life-threatening outcomes mandating percutaneous coronary intervention. We highlight possible pathophysiological mechanisms underlying the effects of marijuana on coronary vasculature, making it a potential risk factor for myocardial infarction, and eventual management modalities.