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Clinical experience with a low-dose fixed combination of perindopril plus indapamide in a primary-care setting: the PRETEND study
Vivencio Barrios, Carlos Escobar, Juan Antonio Divison and Francisco MedialdeaPRETEND was a multicenter observational survey carried out in primary-care clinics across Spain. It was designed to determine general practitioners’ perceptions regarding their clinical experience with the fixed low-dose combination of perindopril 2 mg plus indapamide 0.625 mg in everyday practice. A total of 3198 patients, mean age 62.4 ± 10.9 years, were included. Before combined therapy, blood pressure was 161.8 ± 13.0/94.6 ± 9.2 mmHg and after treatment it was 139.8 ± 12.1/82.9 ± 8.4 mmHg (p < 0.001). The blood pressure control rate increased from 1.1 to 38.7%. Most physicians considered the efficacy and tolerability of perindopril plus indapamide to be good or very good, and most patients were satisfied or very satisfied with the therapy.