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Gadofosveset injection for magnetic resonance angiography

Amedeo Chiribiri1, Geraint Morton and Eike Nagel

Magnetic resonance angiography has evolved into a robust clinical tool, with improved performance of both hardware and software. However, the poor signal-to-noise ratio remains an important physical limitation. T1-shortening contrast agents help increase the signal-to-noise-ratio but conventional extracellular agents can be injected only in a limited dosage and this is followed by a rapid decrease in blood concentration caused by redistribution in the extracellular space. Gadofosveset trisodium offers a net increase in T1 relaxivity, blood-pool distribution and a longer half-life, promising to significantly improve magnetic resonance angiography image quality once again.