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High-dose methotrexate complicated by acute tubular necrosis: a case report
Myke R Green, Sajeel A Chowdhary, Lisa M Chalmers, Kris M Lombardi and Marc C ChamberlainHigh-dose methotrexate (HDMTX) forms the basis for the majority of chemotherapy regimens for primary CNS lymphoma. Several toxicities are encountered with HDMTX, of most concern is acute nephrotoxicity. This case report illustrates several aspects of HDMTX-related renal injury.
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