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New-onset diabetes after transplantation: focus on strategies to reduce risk

Adnan Sharif

New-onset diabetes after transplantation (NODAT) is a major and frequent complication post-solid-organ transplantation with significant adverse outcomes associated with its development. Focus amongst transplant clinicians has shifted towards strategies to both predict and prevent the onset of NODAT. Our approach to this problem must incorporate both transplant-specific and nonspecific strategies and appreciate the differences between NODAT and diabetes mellitus with regards to pathophysiology, risk factors, clinical course and management. The complexity of these patients warrants cooperation between clinicians involved within both fields of transplantation and diabetes. This article aims to discuss current strategies to reduce the risk of NODAT and proposes future directions for clinical research.