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Next-generation sequencing technologies and their potential impact on CHO cell-based biomanufacturing

Benjamin Kremkow and Kelvin H Lee

There is growing interest in the possibility of harnessing detailed, mechanistic understanding of the biology of CHO cells to enhance the use of these cells in the manufacturing of biologics. Among the important questions about CHO cells are issues related to productivity, product quality attributes and stability. The advent of next-generation DNA sequencing technologies provides an opportunity to characterize the genome of various host cells and to link genomic changes to phenotypes. In this review, we discuss some of the current and emerging technologies for genome sequencing, their initial applications to CHO bioprocessing, and provide context relative to other omic approaches.