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Oncologic angiogenesis imaging in the clinic: how and why?

Karen A Kurdziel, Liza Lindenberg and Peter L Choyke

The ability to control the growth of new blood vessels would be an extraordinary therapeutic tool for many disease processes. Too often, the promises of discoveries in the basic science arena fail to translate to clinical success. While several anti-angiogenic therapeutics are now US FDA approved, the envisioned clinical benefits have yet to be seen. The ability to clinically noninvasively image angiogenesis would potentially be used to identify patients who may benefit from anti-angiogenic treatments, prognostication/ risk stratification and therapy monitoring. This article reviews the current and future prospects of implementing angiogenesis imaging in the clinic.