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Synthesis and x-ray crystallographic studies of azatricyclo-sulfonamide derivatives

Lakshminarayanan Karthik, Jagadeesan Ganapathy, Pennathur Gautam & Gunasekaran Krishnasamy*

Azatricyclo and its derivatives occupy an important position in medicinal and pesticide chemistry with having a wide range of bioactivities such as antimicrobial, anticancer, antiinflammatory, antibacterial, antifungal and antitumor activities. Similarly, the sulfonamide groups were proved to possess various biological properties such as antimicrobial, antifungal, anticancer, anti-inflammatory, antitubercular and antiviral agents as well as HIV protease
inhibitors. In view of these biological and medicinal importances, X-ray crystallographic studies for the azatricyclo sulfonamide derivatives have been carried out. The structures were solved by direct methods and refinement was carried out using least squares procedures. The detailed information on the molecular conformation in the solid state, IUPAC name and chemical diagram of the compounds are reported.