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The synthesis of p-esters under continuous flow mw conditions

N. Zs. Kiss

Microwave (MW)‐assisted organic syntheses has achieved great attention as laboratory‐scale chemical equipments have been made commercially available. There have since been many reports employing microwave irradiation in organic syntheses, affording higher yields and purity in shorter reaction time as compared to conventional heating methods. However, such reactions are challenging to scale due to the limited penetration depth of microwaves. To address this issue, the application of continuous flow MW reactors are to be considered if the organic transformation meets the requirements of flow chemistry. Such application may be the synthesis of P-esters, phosphinates or phosphonates under continuous flow MW-assisted conditions.