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Unveiling an atypical response to HIV1 infection by the patient carrier of the beta-s globin gene and Duffy antigen gene double mutation

Philomene Lungu Anzwal

The selective pressures exerted by plasmodiums falciparum, vivax, and knowlesi on red blood cells led to the modification of membrane antigens, hemoglobin and enzymes thus leading to the mutation of the Duffy antigen, sickle cell disease, thalassemia and the G6PD deficiency. In this study, it was to determine the impact of the Duffy -46C/C mutation on the low susceptibility and slow progression of HIV infection observed in homozygous sickle-cell anemia. This is a descriptive cross-sectional study conducted on 274 subjects over a period of 4 years, from december 2013 to november 2017, subjects of both sexes whose age ranged between 6 months and 40 years of age and resorted to the detection of HIV antibodies by the Determine test, the viral load by Abbott reel Time, the rate of CD4+ by flow cytometry, electrophoresis of hemoglobin on cellulose acetate at pH 8.5 alkaline and identification of Duffy antigen using indirect Coombs test. The research targeted subjects attending sickle cell care centers in the city of Lubumbashi. The Epi Info 7 software, khi- square, mean and frequency were used. The significance level was set at pÃ