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Immune senescence and cardiomyopathy associated with obesity

Motoaki Sano*, Kohsuke Shirakawa, Tsunehisa Yamamoto

Obesity, diabetes, and metabolic syndrome are common comorbidities in patients with heart failure with preserved ejection fraction. The molecular mechanisms by which these comorbidities promote LV diastolic dysfunction are complex. This review summarizes research performed in mice showing that excessive saturated fatty acid intake causes LV diastolic dysfunction by accelerating immune senescence and increasing cardiomyocyte membrane stiffness, as well as discussing preventive strategies.