சுருக்கம்

Increased Nuchal Translucency Thickness and Perigenetic Results - A Retrospective Cohort Study

Petsava A, Pitsidianaki E, Sfakianaki E, Matalliotaki Ch, Patelarou E, Nikoletakis G and Patelarou A

There is evidence associating the increased nuchal translucency (NT) thickness with the appearance of a form of aneuploidy, heart problems, and other genetic syndromes in the newborn. The present study investigates the possible association of Nuchal Translucency (NT) with intrauterine fetal development and whether the incidence of increased Nuchal Translucency is complicated by genetic syndromes resulting in termination of pregnancy. The present study was based on a retrospective design using the electronic and printed files of the Maternity and Gynecological Clinic of a General Hospital in Greece. The study sample was collected during December of 2019 and consisted of the pregnant women who were under follow up for the period 05/03/2014 - 28/03/2019.  The statistical analysis was conducted using SPSSS 24.0 and Microsoft Excel, while the significance level was determined ≤ 0,05. The sample includes 106 women whose NT thickness is equal to or exceeds the 95th percentage point. The majority of the participants (45.3%) were under 30 years old, 16% of pregnancies ended, while 11% of the newborns experienced a health problem. The 19.8% of the sample had a risk <1:100 of giving birth to a child with the chromosomal abnormality. It was also proved that the older the age of the mother, the biggest the potential of having a health problem in the fetus. Of the pregnancies that had an increased risk of giving birth to a pathological child, 36.4% proceeded to termination of pregnancy and 5% gave birth to a child with a heart problem. A large percentage of the sample had an increased risk of neonatal with a chromosomal abnormality. Finally, the results of the present study support that mother’s age is associated with the risk of newborn health problems. NT is one of the most important tools of the first trimester providing important information about fetal health and development.