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Notch signalling pathway in atherogenesis: Effects in various cell types

Anastasia V. Poznyak, Vasily N. Sukhorukov, Ilya I. Eremin, Irina I. Nadelyaeva, Alexander N. Orekhov

The Notch signaling pathway is one of the fundamental components of cellular signaling. This pathway regulates the choice of cell faith and can enhance proliferation, differentiation, and apoptosis. The role of Notch in cardiovascular system development and functioning is essential. Notch controls various aspects of normal cardiovascular maintenance and pathologies, among which there are pathological cardiac remodeling, ischemia, neoangiogenesis, and others. Atherosclerosis, which is a chronic inflammatory disease, is known for its complex pathogenesis and the variety of cell types involved. In every type of cell, Notch signaling has its specific features. Also, the growing body of evidence suggests that modulating different Notch elements, especially in T-cells, can be a promising strategy to counteract atherosclerosis. In this review, we summarized data on the Notch signaling in different cells during atherogenesis.