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Syndrome of Miscarriage: Linking Obstetric and Age Related Disorders to Early Labor

Emma Bourne

The uterine mucosa, or endometrium, transforms into a robust decidual matrix upon embryo implantation to accommodate the fetal placenta throughout pregnancy. The transformation of endometrial fibroblasts into specialized decidual cells is the driving force behind this change. For decidual homeostasis and expansion in early pregnancy, a coordinated influx of circulating natural killer (NK) cells and bone marrow-derived mesenchymal stem/progenitor cells (BM-MSC) is essential. We hypothesize that miscarriage is linked to subsequent adverse pregnancy outcomes, such as premature labor and loss of another pregnancy, by pathological signals that interfere with the recruitment or activity of extrauterine cells at the maternal-fetal interface. Recurrent miscarriage and age-related disorders, such as cardiometabolic disease, share a common aetiology because NK cells and BM-MSC are important homeostatic regulators in multiple tissues. We propose the term ‘unsuccessful labor condition’ to catch the wellbeing chances related with unnatural birth cycle.

The uterine mucosa, or endometrium, transforms into a robust decidual matrix upon embryo implantation to accommodate the fetal placenta throughout pregnancy. The transformation of endometrial fibroblasts into specialized decidual cells is the driving force behind this change. For decidual homeostasis and expansion in early pregnancy, a coordinated influx of circulating natural killer (NK) cells and bone marrow-derived mesenchymal stem/progenitor cells (BM-MSC) is essential. We hypothesize that miscarriage is linked to subsequent adverse pregnancy outcomes, such as premature labor and loss of another pregnancy, by pathological signals that interfere with the recruitment or activity of extrauterine cells at the maternal-fetal interface. Recurrent miscarriage and age-related disorders, such as cardiometabolic disease, share a common aetiology because NK cells and BM-MSC are important homeostatic regulators in multiple tissues. We propose the term ‘unsuccessful labor condition’ to catch the wellbeing chances related with unnatural birth cycle.